Prevention of Phenytoin-Induced Gingival Overgrowth by Lovastatin in Mice
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چکیده
منابع مشابه
Phenytoin-induced gingival overgrowth.
Gingival overgrowth is a common adverse effect of therapy with Phenytoin, having important medical and cosmetic implications. Poor periodontal hygiene is an important risk factor for severity of Phenytoin-induced gingival overgrowth (PIGO), which is a time-dependent process. There is complex interplay of altered fibroblast biology, connective tissue turnover, inflammatory processes, and growth ...
متن کاملHisto-Pathological Evaluation of Drug Allergy Observed With Gingival Overgrowth Induced by Phenytoin: A Case Report*
Gingival overgrowths are lesions which can be seen due to diffe rent reasons. Phenytoin (PHT), the drug used in the treatment of epilepsy, is probably one of the commonest causes of gingival overgrowth. In the presented case, a male patient aged 23, who has been taking PHT for the treatment of epilepsy, subsequently manifested by the enlarged gingival tissue, which was cut out using gingivectom...
متن کاملAmlodipine-induced gingival overgrowth.
Amlodipine is a calcium channel blocker used in the management of angina and hypertension. We report 3 cases of gingival overgrowth in adult dentate patients associated with chronic usage of this drug. Gingival changes occurred within 3 months of dosage and appeared to be compounded by the patient's existing periodontal condition. In all 3 patients, there was sequestration of amlodipine in thei...
متن کاملDrug-induced Gingival Overgrowth
Many terms have been used to describe gingival overgrowth. The expression gingival hyperplasia (“abnormal increase in the number of normal cells in a normal arrangement in an organ or tissue, which increase in volume”) and gingival hypertrophy (“enlargement or overgrowth of an organ or part due to an increase in size of its constituent cells”) have been also used, although gingival overgrowth i...
متن کاملPhenytoin-induced gingival enlargement.
To cite: Chacko LN, Abraham S. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2014204670 DESCRIPTION Gingival overgrowth occurs as a side effect of some systemic medications. It is now well established that phenytoin is one such agent. It has multiple therapeutic indications ranging from convulsive disorders and neuralgias to cardiac arrhythmia. The incidence rat...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2015
ISSN: 0002-9440
DOI: 10.1016/j.ajpath.2015.02.004